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KMID : 0545120000100060851
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Journal of Microbiology and Biotechnology
2000 Volume.10 No. 6 p.851 ~ p.857
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Enhancement of Phase Il and Antioxidant Enzymes in by Soybeans Fermented with Basidiomycetes
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Shon, Yun Hee
Kim, So Yeun/Lee, Jae Sung/Nam, Kyung Soo
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Abstract
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The activities of phase Ⅱ and antioxidant enzymes in the liver, lung, kidney, stomach, and colon of mice were examined following intragastric application of polysaccharides extracted from soybeans fermented with either Agrocybe cylindracea (AC) or Phellinus igniarius (PI). The intragastric application of the extracts to mice for 14 days significantly increased the activities of quinone reductase (QR) and glutathione S-transferase (GST) in the liver and kidney, glutathione (GSH) and superoxide dismutase (SOD) in the liver, kidney, lung, and stomach, and glutathione peroxidase (GSH-Px) in the liver, lung, and kidney. In general, the elevation of the phase Ⅱ and antioxidant enzymes activities was more pronounced in the liver and kidney as compared to the lung, stomach, and colon. Accordingly, these findings suggest that polysaccharides extracted from soybeans fermented with A. cylindracea or P igniarius have a cancer chemopreventive potential in various target organs.
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